The past year was the second one the Laboratory of Ion Beam Physics had to operate under restrictions given by the Covid-19 pandemic situation. Despite the difficulties to maintain routine operation and the limited personnel interaction caused by mandatory or advised home office obligations, we had some scientific highlights in 2021. One highlight of the year was the triennial AMS conference, which was held fully online, a novelty in its 43-year long history. The fact that the conference schedule was based on Australian Eastern Daylight Time was challenging, but still many LIP scientists and PhD students presented their work online in the form of pre-recorded video presentations and posters. With best poster and best poster plus awards the conference was particularly successful for two of our PhD students. Also, the scientific output of LIP was exceptional this year. Scientific publications in peer reviewed journals with LIP members as first or contributing authors almost reached the number of one hundred. Among those, a remarkable number of publications was published in top ranked journals, underlining the relevance of research at LIP. This report is intended to briefly summarize the board research activities of the laboratory. We hope that reading it will stimulate your curiosity and that you might want to follow up with the related scientific literature as given in the publication list. We are continuing our commitment of providing excellent service to external and internal users, we contribute significantly to their scientific output and careers. In 2021, more than 18’000 individual analyses have been made on our instruments. In addition, LIP scientists and staff are deeply engaged in the training of students and apprentices at all levels of their careers and in many different departments, which makes LIP an important player in fulfilling the educational mission of ETH. We are looking forward to return to normal working conditions, to reactivate in person discussions and exchange of scientific ideas. Finally, we want to thank all LIP users and collaborators for their contributions to this volume. It is their trust and confidence that motivates us to refine and further exploit the powerful opportunities of ion beam technology and the related applications. Hans-Arno Synal and Marcus Christlweiterlesen