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Antimalarial Natural Products

Produktform: E-Buch Text Elektronisches Buch in proprietärem

This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature’s combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends by identifying ten natural products with development potential as clinical antimalarial agents.weiterlesen

Dieser Artikel gehört zu den folgenden Serien

Elektronisches Format: PDF

Sprache(n): Englisch

ISBN: 978-3-030-89873-1 / 978-3030898731 / 9783030898731

Verlag: Springer International Publishing

Erscheinungsdatum: 02.01.2022

Seiten: 106

Herausgegeben von A. Douglas Kinghorn, Heinz Falk, Yoshinori Asakawa, Simon Gibbons, Ji-Kai Liu, Verena M. Dirsch

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