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Assessing Rare Variation in Complex Traits

Design and Analysis of Genetic Studies

Produktform: E-Buch Text Elektronisches Buch in proprietärem

Genetic association studies have in the last few years substantially enhanced our understanding of factors underlying traits of high medical importance, such as body mass index, lipid levels, blood pressure and many others. There is growing empirical evidence that low-frequency and rare variants play an important role in complex human phenotypes. This book covers multiple aspects of study design, analysis and interpretation for complex trait studies focusing on rare sequence variation. In many areas of genomic research, including complex trait association studies, technology is in danger of outstripping our capacity to analyse and interpret the vast amounts of data generated. The field of statistical genetics in the whole-genome sequencing era is still in its infancy, but powerful methods to analyse the aggregation of low-frequency and rare variants are now starting to emerge. weiterlesen

Elektronisches Format: PDF

Sprache(n): Englisch

ISBN: 978-1-4939-2824-8 / 978-1493928248 / 9781493928248

Verlag: Springer US

Erscheinungsdatum: 13.08.2015

Seiten: 263

Herausgegeben von Eleftheria Zeggini, Andrew Morris, Ph.D., Andrew Morris

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