Frontmatter -- PREFACE -- LIST OF PARTICIPANTS -- CONTENTS -- SECTION I. BASIC ASPECTS OF IMMUNITY TO INSULIN -- Introduction: Insulin as a tool for the study of immunological problems / Keck, K. -- Genetic control of the immune response to insulin / Rosenthal, A. S. / Lin, C. S. / Hansen, T. / Thomas, J. W. / Danho, W. / Bullesbach, E. / Föhles, J. -- Analysis of the in vitro induction of insulin-specific helper T cells / Ramila, G. / Sklenar, I. / Vogt, P. / Studer, S. / Zoumbou, E. / Erb, P. -- Immunogenic determinants of insulin: Synthesis and immunogenicity of the A-chain loop peptides of beef insulin / Singh, B. / Fraga, E. -- Analysis of H-2 gene regulation of the response of T lymphocytes to insulin using synthetic antigenic determinants and anti-idiotypes / Talmon, Janet / Maron, Ruth / Gotlib, Esther / Cohen, Irun R. -- Ir gene control of the insulin-specific immune response in mice / Kapp, J. A. / Bucy, R. P. -- Influence of insulin modification upon the immune response to insulin / Thomas, J. W. / Kapp, J. A. / Schroer, J. A. / Rosenthal, A. S. -- Function and complementation of Ir genes controlling the responsiveness of mice to insulin / Spaeth, E. / Stötter, H. / Reske-Kunz, A. / Zimmermann, F. / Rude, E. / Hedrich, H. J. -- The XID gene controls Ia.W39 associated immune response gene function for insulin induced T cell activation / Rosenwasser, L. J. / Huber, B. T. -- Induction of immunity and suppression by pig insulin in mice / Momayezi, M. / Keck, K. -- Genetic control of anti-insulin responses is associated with activation of different T-cell sets / Abromson-Leeman, S. / Rapp, B. J. / Cantor, H. -- Suppression of insulin responses in vitro / Kontiainen, Sirkka / Scheinin, Tom -- Immune response phenotype of insulin-presenting cells modified by insertion of H-2 gene products into cell membranes / Prujansky-Jakobovitz, A. / Frenkel, A. / Sharon, N. / Cohen, I. R. -- Differences in insulin antibodies induced with varying antigenic forms / Arquilla, E. R. / Valdes, I. / Thompson, R. / Michalski, R. E. / Thomas, K. -- Mouse hybridoma antibody recognition of the insulin molecule / Schroer, J. -- SECTION II. CLINICAL ASPECTS OF IMMUNITY TO INSULIN -- Clinical aspects of immunity to insulin / Federlin, K. / Velcovsky, H. G. / Maser, E. -- Antibody production during insulin therapy - patterns of response and clinical sequels / Reeves, W. G. -- Studies of the immunogenicity of chromatographically purified insulins in Type-I and Type-II diabetics / Velcovsky, H.-G. / Mäser, E. / Federlin, K. -- Genetic control of the IgE response to insulin / Kallenberger, I. / Keck, K. -- HLA-DR association of humoral immunoresponsiveness to insulin in insulin-dependent (Type I) diabetes mellitus / Bertrams, J. / Grüneklee, D. -- Insulin antibody formation following conventional or monocomponent insulin treatment is influenced by genes of the HLA-DR locus / Schernthaner, G. / Mayr, W. R. -- A study of HLA alloantigen frequencies in insulin allergic and non-allergic diabetics / Mann, D. L. / Rosenthal, A. S. / Kahn, R. / Johnson, A. H. / Mendell, N. -- Morphologic changes in pancreas islets after active or passive immunization against insulin: a review / Freytag, G. -- The role of autoimmune processes in the development of insulin-dependent diabetes mellitus in mice treated with streptozotocin / Shin, S. / Paik, S.-G. / Fleischer, N. -- Effect of insulin-binding antibodies of free insulin in plasma and tissue after subcutaneous injection. A model study / Kruse, V. -- Immunogenicity of insulin in relation to its physicochemical properties / Hansen, B. / Nielsen, J. Høiriis / Welinder, B. -- Potentation of insulin immunogenicity by different types of adjuvant / Neubauer, H. P. / Schöne, H. H. -- Use of modified insulins for the separation of insulin antibodies by affinity chromatography / Petersen, K.-G. / Schlüter, K. / Schüttler, A. / Brandenburg, D. -- The immunogenicity of insulin from our point of view / Neubauer, H. P. / Schöne, H. H. -- SECTION III. CHEMISTRY TO INSULIN -- Preparation of insulins with modified N-terminals by semisynthesis and chemical modification of the native hormone / Brandenburg, Dietrich / Weimann, Hans-Josef / Trindler, Peter / Schüttler, Achim -- Synthesis of insulin analogues / Büllesbach, Erika E. / Brandenburg, Dietrich -- Modification of the C-terminal region of insulin / Gattner, H.-G. / Danho, W. / Knorr, R. / Naithani, V. K. / Schmitt, E. W. / Zahn, H. -- SUBJECT INDEX -- AUTHOR INDEXweiterlesen