Colorectal cancer is the third most commonly diagnosed condition in oncology, affecting around 1.23 million individuals per year, according to recent statistics. Of these patients, about 50% will develop liver metastases and approximately 20% will present a stage IV disease at diagnosis. These statistics make colorectal liver metastases (CLM) an issue of major importance in current oncology.  The area of CLM is subject to great and continuous advances, as its pathophysiologic mechanisms are better understood and more therapeutic and surgical options are developed. Consequently, all professionals involved with the diagnosis, treatment and follow up of CLM should be kept up to date with the latest advances on the field, to provide high standard medical care to their patients.  This book is designed to present the state-of-the-art in CLM management and, in doing so, to review the current evidence on CLM, discussing all important topics in the field. Coverage will be broad and comprehensive, encompassing introductory topics (history, definitions, epidemiology, etc.), basic science subjects (molecular biology, genetics, dissemination process, etc.) and practical clinical topics (tumor behavior, diagnosis, drug therapy, radiation therapy, surgery, ablation, multidisciplinary teams, etc.).  Although comprehensive on the coverage and selection of topics, each chapter should be concise and objective, dissecting topics on a practical and direct format. Chapters will display a brief introduction of the common knowledge and go straight to the detailed revision of the most recent years of the literature. Systematic reviews will be encouraged and used when there is enough evidence available. Levels of evidence and grade of recommendation will be included and chapters will be finished with practical closing observations.   This book is planned to be a tool for professionals (general and cancer surgeons, HPB surgeons, clinical oncologists, gastroenterologists and medical residents) and interns who search for a qualified and reader friendly revision on topics concerning Colorectal Cancer Liver Metastases. To keep the book up-to-date and coherent with the most recent advances, editors intend to prepare new editions every two years, consequently making it a consistent, practical update for the field. In this context this book is expected to become the preferred update source on CLM. weiterlesen