gathers the proceedings of the I-ESA’22 Conference, which was organised by the Universidad Politécnica de Valencia, on behalf of INTERVAL and the European Virtual Laboratory for Enterprise Interoperability (INTEROP-VLab), and was held in Valencia, Spain in March 2022. It presents contributions ranging from academic research and case studies, to industrial and administrative experiences with interoperability that help organizations to assist them in analysis and improvement of their products and processes in the face of the high degree of uncertainty in the current commercial environment, and to predict their performance.To this end, the contributors exploit digital twin technology that integrates tools from the Internet of Things, artificial intelligence and software analytics. Enterprise interoperability necessarily arises from the processes required to make associated digital twins work together. weiterlesen