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Genome-Wide Association Studies and Genomic Prediction

Produktform: E-Buch Text Elektronisches Buch in proprietärem

With the detailed genomic information that is now becoming available, we have a plethora of data that allows researchers to address questions in a variety of areas. Genome-wide association studies (GWAS) have become a vital approach to identify candidate regions associated with complex diseases in human medicine, production traits in agriculture, and variation in wild populations.  Genomic prediction goes a step further, attempting to predict phenotypic variation in these traits from genomic information.  pulls together expert contributions to address this important area of study.  The volume begins with a section covering the phenotypes of interest as well as design issues for GWAS, then moves on to discuss efficient computational methods to store and handle large datasets, quality control measures, phasing, haplotype inference, and imputation.  Later chapters deal with statistical approaches to data analysis where the experimental objective is either to confirm the biology by identifying genomic regions associated to a trait or to use the data to make genomic predictions about a future phenotypic outcome (e.g. predict onset of disease). As part of the series, chapters provide helpful, real-world implementation advice.weiterlesen

Dieser Artikel gehört zu den folgenden Serien

Elektronisches Format: PDF

Sprache(n): Englisch

ISBN: 978-1-62703-447-0 / 978-1627034470 / 9781627034470

Verlag: Humana Press

Erscheinungsdatum: 12.06.2013

Seiten: 566

Herausgegeben von Julius van der Werf, Cedric Gondro, Ben Hayes

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