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Molecular Basis for Mitochondrial Signaling

Produktform: E-Buch Text Elektronisches Buch in proprietärem

This book covers recent advances in the study of structure, function, and regulation of metabolite, protein and ion translocating channels, and transporters in mitochondria. A wide array of cutting-edge methods are covered, ranging from electrophysiology and cell biology to bioinformatics, as well as structural, systems, and computational biology. At last, the molecular identity of two important channels in the mitochondrial inner membrane, the mitochondrial calcium uniporter and the mitochondrial permeability transition pore have been established. After years of work on the physiology and structure of VDAC channels in the mitochondrial outer membrane, there have been multiple discoveries on VDAC permeation and regulation by cytosolic proteins. Recent breakthroughs in structural studies of the mitochondrial cholesterol translocator reveal a set of novel unexpected features and provide essential clues for defining therapeutic strategies. covers these and many more recent studies of mitochondria function, their communication with other organelles, and their critical roles in development, aging, and in a plethora of stressful or degenerative events. Authored by leading researchers in the field, this volume will be an indispensable reference resource for graduate students and academics working in related areas of biophysics and cell biology as well as for professionals within industry.weiterlesen

Dieser Artikel gehört zu den folgenden Serien

Elektronisches Format: PDF

Sprache(n): Englisch

ISBN: 978-3-319-55539-3 / 978-3319555393 / 9783319555393

Verlag: Springer International Publishing

Erscheinungsdatum: 12.05.2017

Seiten: 386

Herausgegeben von Tatiana K. Rostovtseva

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