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Molecular Neurosurgery with Targeted Toxins

Produktform: E-Buch Text Elektronisches Buch in proprietärem

Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals is treated in detail to give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of CNS demyelination are explained by experts in the field.weiterlesen

Elektronisches Format: PDF

Sprache(n): Englisch

ISBN: 978-1-59259-896-0 / 978-1592598960 / 9781592598960

Verlag: Humana Press

Erscheinungsdatum: 10.10.2007

Seiten: 312

Herausgegeben von Ronald G. Wiley, Douglas A. Lappi

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