This book constitutes the refereed proceedings of the 16th International Conference on Multi-disciplinary Trends in Artificial Intelligence, MIWAI 2023, held in Hyderabad, India, during July 21–22, 2023, 2022.The 47 full papers and 24 short papers included in this book were carefully reviewed and selected from 245 submissions. They were organized in topical sections as follows: digital life: an advent of transhumanism; traveling salesperson problem; and centrality measures based heuristics for perfect awareness problem in social networks. weiterlesen