The Low-Dose Ozone Concept as Bioregulator of Cellular Antioxidants and Immune Modulator. Over the last 20 years OZONE OXYGEN Therapy in the form ofthe low dose ozone concept has developed into an established complementary treatment method on a sound scientific basis. Its biochemical action and pharmacological properties have been well investigated, documented and published in internationally recognized journals in the context of its classical indications. Following the international classification of evidenced-based medicine, the main systemic ozone applications, the major autohemotherapy and rectal insufflation, are evidence-based. Chronic inflammatory processes or diseases associated with chronic inflammations, always accompanied by high oxidative stress, represent the main ozone indications: • Angiopathia and arterial circulatory disorders • Rheumatoid arthritis, Pain management • Hepatitis • Complementary oncology On the basis of the internationally published Guidelines, the standardized forms of applications, the indications, concentrations, doses and frequency of treatment as based on the mechanism of action and the pharmacology of ozone, are presented in this practical handbook, as well as the pharmacodynamics and pharmacokinetics of medical ozone.weiterlesen