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Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers

Produktform: E-Buch Text Elektronisches Buch in proprietärem

Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy.  The tumor’s increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance. weiterlesen

Elektronisches Format: PDF

Sprache(n): Englisch

ISBN: 978-3-030-48405-7 / 978-3030484057 / 9783030484057

Verlag: Springer International Publishing

Erscheinungsdatum: 07.10.2020

Seiten: 340

Herausgegeben von Ganji Purnachandra Nagaraju

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