Radiological and histomorphometric comparison of degradation behavior and osseointegration of PEO-surface-modified and non-surface-modified ZX00-based magnesium implants: An in vivo study after 6,12 and 18 months in the Minipig In the past the surgical treatment of fractures with resorbable magnesium-based osteosynthesis materials has been shown to be advantageous over non-resorbable osteosynthesis materials such as titanium or resorbable polymer-based osteosynthesis materials for some indications. The limitation for routine use is the hydrogen gas released during degradation, which led to subcutaneous and intraosseous gas accumulation around the implant in previous studies. To ensure stable bone-implant contact during fracture healing and to avoid adverse effects in the bone around the implant during the degradation process, alloying and coating of magnesium-based implants was used to try to slow down degradation. The aim of this doctoral thesis was thus to investigate the degradation behavior as well as the reaction of the surrounding bone to ZX00 implants with and without PEO surface modification in a large animal experiment after 6, 12 and 18 months of implantation. For this purpose, the implants were placed in the frontal bone of minipigs and analyzed radiologically and histomorphometrically after the respective standing time. The implants were explanted with the surrounding bone. The residual volume was calculated in the micro-CT examination based on the density of the material (SV/TV). In the histomorphometric examination, the proportion of the remaining implant material was calculated using the area of the implant’s cross-section (SA/TA). The results of the radiological and the histomorphometric evaluation show a higher residual volume of PEO surface-coated implants at all time points and prove the successful delay of magnesium corrosion. Significant differences were seen in the radiological evaluation after 12 and 18 months of implantation (p weiterlesen