In a world where innovation is considered to be a key driver for a new economy, Higher Education Institutions (HEI) can play a pivotal role. With this understanding, HEI in Latin America, have become significantly more entrepreneurial over the last decade. UniTransfer, the project that gave birth to this book, emerges as a response to a better understanding of the nature of knowledge and technology transfer (KTT), and ways to implement change from within the structures of HEIs in Central America and Mexico. This publication portrays the projects developed by the participants. Each chapter constitutes an approach and a good practice that can be further consulted by any other academic institution in a similar context striving for change to success.